首页|The Warburg effect might result from the generation of dominating paternal vs. maternal genome in carcinogenesis.
The Warburg effect might result from the generation of dominating paternal vs. maternal genome in carcinogenesis.
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NSTL
Previously， based on the fact that the paternal genome tend to be growth-promoting while the maternal genome growth-limiting， we proposed that carcinogenesis might be a chain reaction of aneuploidization companied by gains of paternal genome while loses of maternal chromosomes， which ultimately generate paternal chromosomes dominated maternal genome of cancer cells 。 This suggestion seems to well explain the similarities between trophoblast and cancer cells in proliferation， invasion， migration， vasculature and escaping from the immune system 。 Here we further suggest that this hypothesis should perfectly explain the Warburg effect of malignance。 Over 70 years ago， Otto Warburg made the surprising finding that tumor cells， unlike their normal counterparts， utilize glycolysis instead of mitochondrial oxidative phosphorylation for glucose metabolism even when in oxygen-rich conditions (the Warburg effect) 。 Warburg called this unusual phenomenon "aerobic glycolysis" and suggested that mitochondrial defects might be central to cancer cell biology 。 Since Warburg's proposal， a variety of differences between cancer mitochondria and normal cell mitochondria have been identified， including a general down-regulation of mitochondrial number and oxidative phosphorylation enzymes in cancer cells 。 Recently somatic mitochondrial DNA (mtDNA) deletions， point mutations and microsatellite instability have been reported in various human cancers 。 It seems that these results confirm Warburg's hypothesis。
NSTL
