Fitoterapia2022，Vol.1569.DOI:10.1016/j.fitote.2021.105087

Three novel alkaloids from Portulaca oleracea L. and their anti-inflammatory bioactivities

Song M. Ying X. Ying Z. Yang G. Jia L.
Fitoterapia2022，Vol.1569.DOI:10.1016/j.fitote.2021.105087
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  • NSTL
  • Elsevier

Three novel alkaloids from Portulaca oleracea L. and their anti-inflammatory bioactivities

Song M. 1Ying X. 1Ying Z. 2Yang G. 2Jia L.3
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作者信息

  • 1. School of Pharmacy Liaoning University of Traditional Chinese Medicine
  • 2. School of The First Clinic Liaoning University of Traditional Chinese Medicine
  • 3. Key Laboratory of Ministry of Education for TCM Viscera-State Theory and Applications Liaoning University of Traditional Chinese Medicine
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Abstract

? 2021 Elsevier B.V.Three novel alkaloids, identified as (E)-N-((2R)-3-(2,5-dihydroxy-4-((3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)phenyl)-2-hydroxypropanoyl)-3-(4-hydroxyphenyl)acrylamide (1), named oleracrylimide A, (E)-N-((2R)-3-(2,5-dihydroxy-4-((3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)phenyl)-2-hydroxypropanoyl)-3-(4-hydroxy-3-methoxyphenyl)acrylamide (2), named oleracrylimide B, and (E)-N-((2R)-3-(2,5-dihydroxy-4-((3,4,5-trihydroxy-6-(((3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)phenyl)-2-hydroxypropanoyl)-3-(4-hydroxy-3-methoxyphenyl)acrylamide (3), named oleracrylimide C were isolated from Portulaca oleracea L. and the structures of the three novel compounds were determined by 1D and 2D NMR, circular dichroism, and UHPLC-ESI-QTOF/MS spectroscopic methods. Moreover, the bioactivities of anti-inflammation of the three compounds were investigated via testing RAW 264.7 macrophage cell stimulated by Lipopolysaccharide.

Key words

Alkaloid/Anti-inflammatory bioactivity/Portulaca oleracea L.

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出版年

2022
Fitoterapia

Fitoterapia

SCI
ISSN：0367-326X
被引量7
参考文献量34
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