首页|Cytotoxic alkaloids from the root of Zanthoxylum paracanthum (mildbr) Kokwaro

Cytotoxic alkaloids from the root of Zanthoxylum paracanthum (mildbr) Kokwaro

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  • Taylor & Francis
Abstract Chemical investigation of the root of Zanthoxylum paracanthum afforded 1 new alkamide derivative, (2E,4E)-6-oxo-N-isobutyldeca-2,4-dienamide (1) together with 10 known congeners including one phenolic amide (2), four benzophenanthridines (3???6), three indolonaphthyridines (7???9) and two lignans (10 and 11). Their structures were elucidated by a combination of spectroscopic and spectrometric data. Using resazurin reduction assay, the crude extract (10?μg/mL) and isolates (10?μM) were screened for their cytotoxic activities against the drug-sensitive (CCRF-CEM) leukemia cell line and its multidrug-resistant counterpart (CEM/ADR5000). Compounds 3, 4 and 6 showed cytotoxicity against CCRF-CEM with IC50 values of 2.00?±?0.33, 2.31?±?0.20 and 0.11?±?0.04?μM, respectively. Only compound 6 exhibited strong cytotoxic activity against CEM/ADR5000 with an IC50 value of 2.34?±?0.34?μM in comparison with the standard drug doxorubicin which showed IC50 values of 0.01?±?0.14 (CCRF-CEM) and 26.78?±?3.30?μM (CEM/ADR5000).

Zanthoxylum paracanthumRutaceaealkamidecytotoxicity

Leonidah Kerubo,Omosa、Vaderament-A,Nchiozem-Ngnitedem、Justus,Mukavi、Brenda,Atieno Okoko、Helder,Ombui Nyaboke、Ibrahim,Hashim、Jackson,Obegi Matundura、Thomas,Efferth、Michael,Spiteller

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Department of Chemistry, University of Nairobi

School of Pure and Applied Sciences, University of Embu

Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes

Institute of Environmental Research (INFU), Department of Chemistry and Chemical Biology, Chair of

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2022

10.1080/14786419.2021.1913586

Natural product research

Natural product research

SCI
ISSN：1478-6419
年,卷(期)：2022.36(10/12)
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