首页|Steroidal alkaloids from Solanum erianthum and their anti-breast cancer properties
Steroidal alkaloids from Solanum erianthum and their anti-breast cancer properties
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NSTL
Elsevier
? 2022 Phytochemical Society of EuropeTwo new glycoalkaloids, erianosides A (1) and B (2) along with five known compounds (3–7) were isolated from the leaves of Solanum erianthum. Their structures were elucidated from analyses of spectroscopic data and all isolates were tested for in vitro cytotoxic activity against human breast cancer cell lines (BT-549, MDA-MB-231, T74D, and MCF-7). Solasonine (5) and solamargine (6) were active against the aforementioned four cancer cell lines with IC50 values of 27.26–35.89 and 5.84–10.13 μM, respectively. Erianoside A (1) (T74D: IC50, 56.39 μM) and solasodine (3) (BT-549 and MDA-MB-231: IC50, 59.15 and 75.63 μM, respectively) had moderate cytotoxic effects towards some cell lines in the panel.
Anti-breast cancer cell linesSolanaceaeSolanum erianthumSteroidal alkaloids
Lee C.-L.、Hsu W.-Y.、Wu Y.-C.、Chen C.-J.
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Department of Cosmeceutics China Medical University
Chinese Medicine Research and Development Center China Medical University Hospital
Graduate Institute of Integrated Medicine China Medical University
NSTL
Elsevier
