Cytotoxic and alpha-glucosidase inhibitory metabolites from twigs and leaves of Phyllanthus mirabilis, a species endemic to limestone mountains

Phukhatmuen, Piyaporn ¹Pornpongrungrueng, Pimwadee ²Kanokmedhakul, Somdej ²Somteds, Apisara ²Kanokmedhakul, Kwanjai ²Chaiyosang, Boonyanoot ²Yahuafai, Jantana ³Laphookhieo, Surat¹

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作者信息

1. Mae Fah Luang Univ
2. Khon Kaen Univ
3. Res Div Natl Canc Inst
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Abstract

The first investigation of Phyllanthus mirabilis Mull.Arg. led to the isolation of six undescribed compounds including two tyramine derivatives: phyllatyramines A and B; three butenolide analogues, phyllantenolide, phyllantenocoside-O-gallate and epi-phyllantenocoside-O-gallate; and a flavanonol gallate, (-)-taxifolin-3-Ogallate; as well as two first isolated natural products, phyllatyramine C and phyllantenocoside; together with twenty-three known compounds. Their structures were elucidated by spectroscopic means. ECD spectra of all isolated butenolides were compared and assigned the configurations. Phyllatyramine A displayed weak cytotoxicity against the KB cell line, while phyllatyramines B and C showed weak cytotoxicity against KB and HeLa cell lines. In addition, phyllatyramine B and (-)-taxifolin-3-O-gallate showed more potent alpha-glucosidase inhibitory activity than the standard acarbose 3.4 and 5.8 fold, respectively.

Key words

Phyllanthus mirabilis/Phyllanthaceae/Cytotoxicity/alpha-Glucosidase inhibitory/Tyramine derivative/Butenolide glucoside/Taxifolin-3-O-gallate/ANTIOXIDANT/CONSTITUENTS/DERIVATIVES/INDUCTION/CELLS/PLANT

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出版年

2022

Phytochemistry

CCR

ISSN：0031-9422

参考文献量44

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