首页|Mucolytic self-emulsifying drug delivery systems (SEDDS) containing a hydrophobic ion-pair of proteinase
Mucolytic self-emulsifying drug delivery systems (SEDDS) containing a hydrophobic ion-pair of proteinase
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NSTL
Elsevier
Aim: The aim of this study was to form hydrophobic ion-pairs of proteinase with cationic surfactants and to incorporate them into self-emulsifying drug delivery systems (SEDDS) to improve their mucus permeating properties. Methods: Proteinase was ion-paired with benzalkonium chloride (BAK), hexadecylpyridinium chloride (HDP), alkyltrimethylammonium bromide (ATA) and hexadecyltrimethylammonium bromide (HDT) at pH 8.5-9.0, and subsequently incorporated into SEDDS consisting of Cremophor EL, propylene glycol, and Capmul 808-G (40/ 20/40). Mucus permeation of SEDDS containing proteinase complexes was evaluated via rotating tube technique and cell-free Transwell (R) insert system. Additionally, enzymatic activity of proteinase complexes as well as their potential cytotoxicity was evaluated.
Mucus permeationSelf-emulsifying drug delivery systems (SEDDS)Hydrophobic ion-pairingCationic surfactantsProteinasemucus
Hung Thanh Lam、Nguyet-Minh Nguyen Le、Thi Nhu Quynh Phan、Bernkop-Schnuerch, Andreas
NSTL
Elsevier
