首页|Targeting breast cancer using pirarubicin-loaded vasoactive intestinal peptide grafted sterically stabilized micelles

Targeting breast cancer using pirarubicin-loaded vasoactive intestinal peptide grafted sterically stabilized micelles

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  • NSTL
  • Elsevier
In this study the chemotherapeutic agent Pirarubicin (PRB) which is known for its serious side effects was actively targeted to the breast cancer cells by uploading it to the biocompatible and biodegradable Sterically Stabilized Micelles (SSMs) made of 1,2-Distearoyl-sn-glycero-3 phosphoethanolamine-N-methoxy-polyethylene glycol 2000 (DSPE-PEG(2000)) to enhance efficacy and reduce toxicity. Vasoactive intestinal peptide (VIP), the receptors of which are overexpressed on the breast cancer cells, was grafted on the surface of the micelles. To the best of our knowledge this is the first report on active targeting of PRB to tumor site.

NanomedicineSterically stabilized micellePirarubicinVIPTargeted cancer therapy

Eskandari, Zahra、Bahadori, Fatemeh、Yapaoz, Melda Altikatoglu、Yenigun, Vildan Betul、Celikten, Mert、Kocyigit, Abdurrahim、Onyuksel, Hayat

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Yildiz Tech Univ, Fac Sci & Arts, Dept Chem, Biochem Div, Istanbul, Turkey

Bezmialem Vakif Univ, Fac Pharm, Dept Pharmaceut Biotechnol, Istanbul, Turkey

Bezmialem Vakif Univ, Fac Med, Dept Med Biochem, Istanbul, Turkey

Bezmialem Vakif Univ, Expt Applicat & Res Ctr, Istanbul, Turkey

Univ Illinois, Dept Biopharmaceut Sci, Chicago, IL 60612 USA

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2021

10.1016/j.ejps.2021.105830

European journal of pharmaceutical sciences

European journal of pharmaceutical sciences

ISTP
ISSN：0928-0987
年,卷(期)：2021.162
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