首页|New quinones, a sesquiterpene and phenol compounds with cytotoxic activity from the aerial parts of Morinda umbellata L.
New quinones, a sesquiterpene and phenol compounds with cytotoxic activity from the aerial parts of Morinda umbellata L.
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NSTL
Elsevier
? 2021 Elsevier B.V.Eight previously undescribed compounds, two quinones (1–2), one sesquiterpene (3), and five phenol compounds (4–8), including three enantiomers (6a, 7a, and 8a), along with three corresponding known enantiomers (6b–8b) were isolated from the aerial parts of Morinda umbellata L. Their structures were elucidated by 1D and 2D NMR spectroscopy, X-ray diffraction, and experimental and calculated ECD spectra, respectively. Compound 5 was found to have weak cytotoxity, which inhibited the growth of seven human cancer cell lines (A2780, HeLa, MCF-7, BGC-823, H7420, Ketr3 and SW 1990) with IC50 values from 13.3 to 15.1 μM.
Li C.、Wang H.、Xie J.、Liu J.、Chen R.、Kang J.、Dong C.、Lai S.
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State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia Medica Chinese Academy of Medical Sciences & Peking Union Medical College
Department of Anesthesiology The First Affiliated Hospital of Jinan University Guangzhou Overseas Chinese Hospital Jinan University
NSTL
Elsevier
