首页|Steroidal components from the roots and rhizomes of Helleborus thibetanus

Steroidal components from the roots and rhizomes of Helleborus thibetanus

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  • NSTL
  • Elsevier
? 2022 Phytochemical Society of EuropeThree new steroidal components hellebogenins A and B (1 – 2) and thibetanoside I (3) together with four know ones (4 – 7) were isolated from the roots and rhizomes of Helleborus thibetanus. Their structures were elucidated by chemical methods and spectroscopic analysis. Among them, compound 1 possessed three double bonds at the positions of 1(2), 5(6) and 25(27), while compound 2 had an α, β unsaturated ketone carbonyl on the A ring. In addition, compounds 1 and 2 showed cytotoxic activities against HCT116 cells with IC50 values of 42.0 ± 1.3 μM and 67.3 ± 1.5 μM, respectively.

CytotoxicityHelleborus thibetanus FranchSteroidal componentsStructure identification

Li Y.、Huang W.、Zhang H.、Jiang Y.、Deng C.、Wang W.、Song X.、Zhang D.、Liu J.

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School of Pharmacy Shaanxi University of Chinese Medicine

Key Laboratory of Resource Biology and Biotechnology in Western China Ministry of Education College of Life Science Northwest University

2022

10.1016/j.phytol.2022.05.007

Phytochemistry Letters

Phytochemistry Letters

SCI
ISSN：1874-3900
年,卷(期)：2022.50
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