Regioselective alkylation of 2,4-dihydroxybenzyaldehydes and 2,4-dihydroxyacetophenones
Frank, Aziza 1Hamidi, Negar 1Xue, Fengtian1
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作者信息
1. Univ Maryland
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Abstract
We report a cesium bicarbonate-mediated alkylation of 2,4-dihydroxybenzyaldehyde and 2,4-dihydroxyacetophenone to generate 4-alkylated products in acetonitrile at 80 degrees C with excellent regioselectivity, up to 95% isolated yields, and broad substrate scope.(c) 2022 Elsevier Ltd. All rights reserved.
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Elsevier