首页|Introduction to Bioisosteric Replacement and Scaffold Hopping in Crop Protection Research
Introduction to Bioisosteric Replacement and Scaffold Hopping in Crop Protection Research
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NSTL
The discovery and development of new agrochemicals has become a difficult and resource-intensive undertaking.In the search for novel active ingredients,the scaffold of a lead often needs to be changed to allow for the respective chemistry class to be optimized.The changes are typically a consequence of issues related to an insufficient level of activity,blocked intellectual property,high complexity of lead compounds(e.g.,natural products),unfavorable metabolic stability,non-ideal physicochemical properties,adverse findings in toxicology studies,and other similar reasons.Scaffold hopping,the replacement of one part of a molecule with another scaffold,and the bioisosteric exchange of rings and functional groups offer the opportunity to either improve the properties of a compound or find similar potent compounds that exist in a new chemical space.
NSTL
