首页|Acanthoic acid, unique potential pimaradiene diterpene isolated from Acanthopanax koreanum Nakai (Araliaceae): A review on its pharmacology, molecular mechanism, and structural modification

Acanthoic acid, unique potential pimaradiene diterpene isolated from Acanthopanax koreanum Nakai (Araliaceae): A review on its pharmacology, molecular mechanism, and structural modification

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  • NSTL
  • Elsevier
? 2022 Elsevier LtdAcanthoic acid (AA) is a pimaradiene diterpene isolated from the root bark of Acanthopanax koreanum Nakai (Araliaceae) with a wide range of pharmacological activities, including anti-cancer, anti-inflammatory, anti-diabetes, liver protection, gastrointestinal protection, and cardiovascular protection. In addition, AA promotes its pharmacological effects by targeting liver X receptors (LXRs), nuclear factor-kappa B (NF-κB), Toll-Like Receptor 4 (TLR4) and IL-1 receptor-associated kinase (IRAK) signaling pathways, or AMP-activated protein kinase (AMPK) signaling pathway, etc. Also, some studies focus on the structural modification of AA to improve its pharmacological activities. The review summarizes the pharmacological activities, molecular mechanism, and the structural modification of AA, which might supply information for the development of AA in the future.

Acanthoic acidAcanthopanax koreanumAraliaceaeMolecular mechanismPharmacological activitiesStructural modification

Dou J.-Y.、Jiang Y.-C.、Cui Z.-Y.、Lian L.-H.、Nan J.-X.、Wu Y.-L.

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Key Laboratory of Traditional Chinese Korean Medicine Research (Yanbian University) College of Pharmacy Yanbian University

2022

10.1016/j.phytochem.2022.113247

Phytochemistry

Phytochemistry

CCR
ISSN：0031-9422
年,卷(期)：2022.200
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