首页|Ferritinophagy in vascular endothelial cells regulated by nanoparticles may benefit the prevention of atherosclerosis and in-stent restenosis
Ferritinophagy in vascular endothelial cells regulated by nanoparticles may benefit the prevention of atherosclerosis and in-stent restenosis
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NSTL
Dear editor, We read the article that revealing the roles of ferritinophagy and ferroptosis in cardiovascular diseases (CVD) with great interest, and this article is helpful for the studies of ferritinophagy and ferroptosis modulators in treating CVD. Here we highlight the role of ferritinophagy in vascular endothelial cells (VEC) regulated by nanoparticles, which may benefit to prevent atherosclerosis (AS) and in-stent restenosis (ISR). Hope this correspondence will enlarge the value of ferritinophagy in CVD. Endothelial lining of lesion-prone areas of coronary artery is an important contributor to the pathology of AS and ISR after percutaneous coronary intervention (PCI) surgery. Stent placement in coronary artery usually causes endothelial injury, while the following step named re-endothelialization, which is depending on the migration of VEC and differentiation of vascular endothelial progenitor cells (VEPC), becomes the main pathology for ISR. Thus, new therapies targeting to the vascular endothelial lineage, especially the CD34~+KDR~+CD45~- progenitor endothelial cells, may help the surface modification of AS and cardiovascular implants.
Qing Liu、Rongyuan Yang、Dawei Wang
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The Second Clinical School of Medicine, Guangzhou University of Chinese Medicine, Guangdong
NSTL
