首页|STEROIDS AND TERPENOIDS FROM THE BARK OF Phyllanthus acidus
STEROIDS AND TERPENOIDS FROM THE BARK OF Phyllanthus acidus
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Phyllanthus acidus(L.)Skeels is a member of Phyllanthaceae that originated from Madagascar and was transplanted to the Caribbean in 1793 when William Bligh brought the plant from Timor to Jamaica [1].It is commonly grown now in farms of Malaysia and Indonesia.It is a highly valued medicinal plant.It has been used by the local people to treat bronchial catarrh [2],skin rashes [3],and as emetic and purgative agents [1,4,5].It has also been reported to have antioxidant [6,7],antimicrobial [8,9],antidiabetic [10],anti-inflammatory [11],and hepatoprotective activities [6,11].As part of our ongoing investigation of bioactive compounds from plant species [12,13],we now investigate the natural compounds of P.acidus.The extraction of the bark of P.acidus afforded three steroids,7-oxo-β-sitosterol(1),β-sitostenone(2),and p-sitosterol(3);and four terpenoids,17p-hydroxy-norlup-20(29)-en-3-one(4),glochidon(5),phyllanthol(6),and squalene(7).Their structures were characterized by extensive spectroscopic methods such as IR,UV,NMR,and MS.All these compounds were isolated for the first time from P.acidus,except for compound 6 [14].
Siow-Ping Таn、Eric Nyak-Yong Таn、Qian-Yu Lim
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Department of Physical Science,Faculty Applied Sciences,Tunku Abdul Rahman University College,53300,Kuala Lumpur,Malaysia
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