首页|Leveraging Extracellular Non-coding RNAs to Diagnose and Treat Heart Diseases
Leveraging Extracellular Non-coding RNAs to Diagnose and Treat Heart Diseases
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NSTL
Springer Nature
Abstract Extracellular vesicles (EVs), including exosomes and microvesicles, emerge to be crucial mediators of cell-to-cell communication in multiple organs. Non-coding RNAs loaded inside EVs contribute as one major mechanism for remote information transfer among different cell types or organs. Increasing evidence suggests that EV-associated non-coding RNAs derived from cardiovascular or non-cardiac cells regulate cardiovascular pathophysiology in heart development and diseases. The functional relevance of the EV-associated ncRNAs in heart diseases provides an avenue to develop novel diagnostic tools and therapies for heart diseases. In this review, we summarize the recent advancement of EV-associated ncRNAs in different cardiovascular diseases, including myocardial infarction, arrhythmias, cardiac hypertrophy, and heart failure, with an emphasis on the underlying molecular mechanisms.
Extracellular vesiclesNon-coding RNAsCardiovascular diseasesCell-to-cell communication
Zhenyi,Zhao、Ningning,Guo、Weixin,Chen、Zhihua,Wang
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School of Pharmacy, Health Science Center,Shenzhen University
Shenzhen Key Laboratory of Cardiovascular Disease,Fuwai Hospital Chinese Academy of Medical
Department of Cardiology,Fuwai Hospital Chinese Academy of Medical Sciences, Shenzhen
NSTL
Springer Nature
