首页|Anti-influenza patchoulol-type sesquiterpenoids from Pogostemon cablin
Anti-influenza patchoulol-type sesquiterpenoids from Pogostemon cablin
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NSTL
Elsevier
? 2022 Phytochemical Society of EuropeFour new patchoulol-type sesquiterpenoids, including 6α,9β-dihydroxypatchoulol 6-O-β-D-glucopyranoside (1), 6α-hydroxypatchoulol 6-O-β-D-glucopyranoside (2), 3α,9β-dihydroxypathoulol (3), and 4β-hydroxynorpatchoulol 4-O-β-D-glucopyranoside (10), were isolated from the roots of Pogostemon cablin (Blanco) Benth, together with eleven known sesquiterpenoids. Their structures were elucidated on the basis of extensive NMR spectral and high resolution mass spectrometry analysis. This is the second report of patchoulol glucopyranoside from P. cablin and compound 10 represented as the first example of nor-patchoulol glucopyranoside. The anti-influenza virus activities of 1–10 against A/WSN/33/2009 and A/Puerto Rico/8/1934 strains (tamiflu resistant viruses) were evaluated. Compounds 2β,12-dihydroxypathoulol (5) and (5R)-5-hydroxypatchoulol (8) exhibited moderate anti-influenza activity against A/WSN/33/2009 strain with EC50 value of 52.7 μM and 49.6 μM (positive control oseltamivir, EC50 = 6.75 μM). Compounds 8 and pogostol (12) showed potent anti-influenza activity against A/Puerto Rico/8/1934 strain with EC50 values of 3.06 μM and 0.07 μM, respectively, versus the postive control (amantadine, EC50 = 67.9 μM).
NSTL
Elsevier
