首页|Bacterial sensing and killing based on fluorescent vesicles formed by cationic Gemini surfactants and AIEgen probe
Bacterial sensing and killing based on fluorescent vesicles formed by cationic Gemini surfactants and AIEgen probe
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In this work,a novel type of vesicles(Vt/g)composed of Gemini cationic surfactant(G12-8-12)and TPE-20H,an AIEgen fluorescence probe,were prepared by methanol evaporation method.Herein,G12-8-12 has good bacteriostatic function.TPE-20H with aggregation-induced emission feature resided in the interlayer of V_(T/G).The average size of V_(T/G)was about 1.2-1.4 pm measured by dynamic light scattering.Zeta potential studies indicated that V_(T/G)could bind to bacteria like S.aureus and E.coli under electrostatic interaction,increasing the size of the complex of Vt/g and bacteria to 4.5-6 μm.Because Vt/g interlayer was compressed by external bacteria,the aggregation degree of TPE-20H was increased,and the fluorescence intensity was increased by 3 times compared with Vt/g alone.The linear increase in fluorescence intensity with the increase of bacteria content implied that it is possible to sense bacteria.After the bacteria were co-incubated with Vt/g,almost no bacteria growth was observed with the light irradiation for 30 min,indicating that V_(T/G)showed good bactericidal effect.This can be ascribed to the synergistic effect of the inherent bactericidal property of G12-8-12 and the oxygen-active substances generated from TPE-20H.This new strategy integrating bacteria detection and killing showed good potential application.
Bacterial sensing and killingFluorescent vesiclesGemini surfactantsAIEgen probe
Xinwei Zhang、Jiao Ma、Kaide Ou
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Key Laboratory of Materials Chemistry for Energy Conversion and Storage of the Ministry of Education,School of Chemistry and Chemical Engineering,Huazhong University of Science and Technology,Wuhan,430074,China
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