首页|Simultaneous quantification of trimethoprim metabolites in pediatric plasma
Simultaneous quantification of trimethoprim metabolites in pediatric plasma
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NSTL
Elsevier
The dual agent antibiotic, trimethoprim/sulfamethoxazole (TMP-SMX), has been prescribed to treat or prevent infections for over 50 years. However, there are no published validated analytical methods for the measurement of TMP metabolites in humans. We developed methodology enabling reliable quantification of TMP and 5 me-tabolites in human plasma. Chromatographic separation was achieved in less than 8 min using a biphenyl col-umn. Analytes were detected in positive electrospray mode using a tandem Waters Xevo-TQ-XS mass spectrometer. Precision and accuracy values for all analytes were within 15% of nominal values during assay validation.
TrimethoprimIdiosynotic adverse drug reactionsMetabolismTandem mass spectrometryValidated methodologySULFAMETHOXAZOLE
Tessman, Robert T.、Nolte, Whitney、Toren, Paul、Gibson, Kim、Vu, Linda、Goldman, Jennifer
NSTL
Elsevier
