首页|An observation study of urinary biomarker exploratory in Alzheimer's disease using high‐resolution mass spectrometry
An observation study of urinary biomarker exploratory in Alzheimer's disease using high‐resolution mass spectrometry
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NSTL
Abstract Alzheimer's disease (AD) is regarded as a progressive neurodegenerative dementia, characterized by degeneration of distinct neuronal populations. A case–control study was carried out using high‐resolution mass spectrometry to explore AD‐associated urinary metabolic biomarkers from 30 AD patients and 30 cognitively normal (CN) individuals. In total, 49 metabolites were determined and validated as known compounds using LC/MS analysis. Using the two‐sample t‐test statistical analysis (P?<?0.05), 19 metabolites were shown to be significantly different from AD to CN. A diagnostic model of the receiver operating characteristic curve was constructed with a combination of nine?molecules out of 19 metabolites, it yielded a separation with an area under the curve value of 0.976 between the two groups. This study indicated that urinary metabolites showed a significant expression between AD and CN. AD‐related metabolites enable to satisfy the diagnostic power of disease discrimination. In addition, as a noninvasive approach, urine collection is done easily in clinical diagnosis of AD.
Alzheimer's diseasehigh‐resolution mass spectrometryurine metabolites
NSTL
