Apolipoprotein E Polymorphism and Alzheimer’s Risk in Kashmiri Population

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NSTL

外文摘要：Although the cause of Alzheimer’s disease is unknown, most experts feel that the disease is caused by a combination of circumstances rather than a single cause. Age, gene polymorphism, diabetes, and other conditions are all risk factors for Alzheimer’s disease. Given the importance of gene polymorphism in different diseases, we intended to find out the association of APOE gene polymorphism with Alzheimer’s risk in the Kashmiri population. Out of 300 patients who were referred to the memory clinicof the hospital, we conducted the study on 59 clinically confirmed Alzheimer’s patients and 52 age and ethnicity-matched healthy controls found in a community survey. Our data revealed a statistically significant association of s4 variant genotype of the APOE gene with AD susceptibility in the Kashmiri population. The current study’s findings provided insight into the role of APOE polymorphisms in Alzheimer’s disease susceptibility. The identified susceptibility variant may become a marker genotype for AD.

外文关键词：

Alzheimer’s disease (AD)Apolipoprotein E (APOE)8283 and s4 isoformsPolymorphismp-Amyloids.

作者：

Kamran Nissar、Arshad Hussain、Bashir Ahmad Ganai

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作者单位：

Department of Biochemistry, Faculty of Biological Sciences, University of Kashmir, Srinagar, Jammu and Kashmir, India

Department of Psychiatry, Faculty of Neurosciences, Institute of Mental Health and Neurosciences, Srinagar, Jammu and Kashmir, India

Centre of Research for Development, Faculty of Multidisciplinary Research Centre, University of Kashmir, Srinagar, Jammu and Kashmir, India.

出版年：

2021

DOI：

org/10.13005/bbra/2950

Biosciences Biotechnology Research Asia

ISSN：0973-1245

年,卷(期)：2021.18(4)