Surface & Coatings Technology2022，Vol.4357.DOI:10.1016/j.surfcoat.2022.128253

Biocompatibility and antimicrobial activity of copper(II) oxide hybridized with nano silicate platelets

Lai, Ping-Shan Lin, Jiang-Jen Yasuda, Kiyokazu Song, Tsing-Tang Song, Jenn-Ming Fernando, Lalani Chen, Wei-Ting Lai, Chung-Wei Ye, Fang-Yi
Surface & Coatings Technology2022，Vol.4357.DOI:10.1016/j.surfcoat.2022.128253
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  • NSTL
  • Elsevier

Biocompatibility and antimicrobial activity of copper(II) oxide hybridized with nano silicate platelets

Lai, Ping-Shan 1Lin, Jiang-Jen 1Yasuda, Kiyokazu 2Song, Tsing-Tang 3Song, Jenn-Ming 1Fernando, Lalani 1Chen, Wei-Ting 1Lai, Chung-Wei 1Ye, Fang-Yi1
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作者信息

  • 1. Natl Chung Hsing Univ
  • 2. Osaka Univ
  • 3. Ind Technol Res Inst
  • 折叠

Abstract

Nano-sized copper(II) oxide (CuO) is an interesting material with proficient antibacterial activities but limited due to its toxicity to mammalian cells. In this study, CuO nano-sized needles were coated on the surface of nano silicate platelets (NSP), which were exfoliated from natural montmorillonite clays and with the thickness of about 1 nm, to form nanohybrids. Our findings indicate that NSPs can effectively prevent the aggregation of CuO needles, and significantly enhance antibacterial efficiency without affecting biocompatibility. An optimal antibacterial activity against Staphylococcus aureus exceeding 99% could be obtained, while that for Escherichia coli was about 88%. Electron paramagnetic resonance results suggest that center dot OH radicals, one of the reactive oxygen species generated by CuO/NSP, might damage the cellular components and thus result in the death of bacterial.

Key words

Nano silicate platelets (NSP)/Biocompatibility/Antimicrobial activity/CuO/Cytotoxicity/ANTIBACTERIAL ACTIVITY/NANOPARTICLES/NANOHYBRIDS/SILVER

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出版年

2022
Surface & Coatings Technology

Surface & Coatings Technology

ISTP
ISSN：0257-8972
被引量1
参考文献量33
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