Cell Response in Free-Packed Granular Systems

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NSTL

外文摘要：The study of the interactions of living adherent cells with mechanically stable(visco)elastic materials enables understanding and exploitation of physiological phenomena mediated by cell-extracellular communication.Insights into the interaction of cells and surrounding objects with different stability patterns upon cell contact might unveil biological responses to engineer innovative applications.Here,we hypothesize that the efficiency of cell attachment,spreading,and movement across a free-packed granular bed of microparticles depends on the microparticle diameter,raising the possibility of a necessary minimum traction force for the reinforcement of cell-particle bonds and long-term cell adhesion.The results suggest that microparticles with diameters of 14-20 μm are prone to cell-mediated mobility,holding the potential of inducing early cell detachment,while objects with diameters from 38 to 85 μm enable long-lasting cell adhesion and proliferation.An in silico hybrid particle-based model that addresses the time-dependent biological mechanisms of cell adhesion is proposed,providing inspiration for engineering platforms to address healthcare-related challenges.

外文关键词：

free-packinggranular systemcell adhesioncell-mediated mobilitycell responsecomputational modeling

作者：

Ana F.Cunha、Andre F.V.Matias、Cristovao S.Dias

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作者单位：

Department of Chemistry,CICECO-Aveiro Institute of Materials,University of Aveiro,3810-193 Aveiro,Portugal

Centro de Fisica Teorica e Computacional,Faculdade de Ciencias,Universidade de Lisboa,1749-016 Lisboa,Portugal

Centro de Fisica Tearica e Computacional,Faculdade de Ciencias,Universidade de Lisboa,1749-016 Lisboa,Portugal

出版年：

2022

DOI：

10.1021/acsarmi.1c24095

ACS applied materials & interfaces

SCI

ISSN：1944-8244

年,卷(期)：2022.14(36)