首页|Chemical composition of five Tunisian Pinus Species’ essential oils and effect of their blends on Otitis infection
Chemical composition of five Tunisian Pinus Species’ essential oils and effect of their blends on Otitis infection
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NSTL
Elsevier
? 2022 Elsevier B.V.Many studies reported the chemical composition and the biological activities of Pinus Essential oils (EOs). A few of them were investigated for their antibacterial activity against strains responsible for otitis. The present paper investigated the variation of the chemical composition and the antibacterial activity of the EOs of five Tunisian Pinus species and of their combinations against six bacterial strains responsible for otitis. The EOs’ yields varied from 0.3 ± 0.1% for P. pinea to 1.8 ± 0.4% for P. halepensis. Their chromatographic analyses by GC and GC-MS identified 139 components varying according to the species. The main components were β-pinene followed by trans-caryophyllene, germacrene D, α-pinene, β-myrcene, palustradiene, abieta-7,13-triene, levopimaradiene, thunbergol, and caryophyllene oxide. Four chemical groups were identified basing on the PCA and the HCA of the 25major's components of the studied EOs. However, three subgroups were identified within the antibacterial-based PCA and HCA analyses. The highest antibacterial activity was observed with the blends of oils extracted from P. halepensis and P. canariensis and mixture of oils extracted from P. brutia and P. canariensis. These EOs blends may constitute promising antibiotic alternatives for the treatment of the otitis media.
Ameur E.、Sarra M.E.、Takoua K.、Mariem K.、Larbi K.M.、Nabil A.、Lynen F.
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Chemical Pharmacological and Gallenic Development Laboratory University of Monastir Faculty of Pharmacy
University of Carthage The National Research Institute of Rural Engineering Water and Forestry INRGREF Laboratory of Management and Valorization of Forest Resources
Laboratory of Transmissible Diseases and Biological Active Substances LR99ES27 Faculty of Pharmacy University of Monastir
Separation Science Group Department of Organic and Macromolecular Chemistry Faculty of Sciences Ghent University
NSTL
Elsevier
