首页|Base-promoted cascade radical difluoroalkylation/cyclization of acrylamides for the synthesis of CF2-containing oxindoles and isoquinoline-1,3-diones
Base-promoted cascade radical difluoroalkylation/cyclization of acrylamides for the synthesis of CF2-containing oxindoles and isoquinoline-1,3-diones
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NSTL
Elsevier
A base-promoted cascade radical difluoroalkylation/cyclization of acrylamides with ICF2COOEt to synthesize CF2-containing oxindoles and isoquinoline-1,3-diones in moderate to excellent yields was developed under transition metal-free and catalyst-free conditions. This reaction tolerated a variety of functional groups and provided an alternative and mild method for the preparation of difluoroester-substituted fiveand six-membered nitrogen-containing heterocyclic products.
NSTL
Elsevier
