Fitoterapia2022，Vol.1586.DOI:10.1016/j.fitote.2022.105162

LC-MS-guided isolation of 2-(2-phenylethyl)chromone dimers from red soil agarwood of Aquilaria crassna

Yang L. Yuan J.-Z. Gai C.-J. Cai C.-H. Dai H.-F. Mei W.-L. He D. Dong W.-H. Li W. Wang H.
Fitoterapia2022，Vol.1586.DOI:10.1016/j.fitote.2022.105162
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  • NSTL
  • Elsevier

LC-MS-guided isolation of 2-(2-phenylethyl)chromone dimers from red soil agarwood of Aquilaria crassna

Yang L. 1Yuan J.-Z. 1Gai C.-J. 1Cai C.-H. 1Dai H.-F. 1Mei W.-L. 1He D. 1Dong W.-H. 1Li W. 1Wang H.1
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作者信息

  • 1. Hainan Engineering Research Center of Agarwood Hainan Institute for Tropical Agricultural Resources Institute of Tropical Bioscience and Biotechnology Chinese Academy of Tropical Agricultural Sciences
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Abstract

? 2022 Elsevier B.V.Six new 2-(2-phenylethyl)chromone dimers (1–6) were isolated from ethyl ether extract of red soil agarwood of Aquilaria crassna from Vietnam by LC-MS-guided fractionation procedure. Their structures were unambiguously elucidated based on HRESIMS, 1D and 2D NMR spectra. The absolute configuration of 2-(2-phenylethyl)chromone dimers was determined by comparison of the experimental and computed ECD spectra. Compound 6 displayed cytotoxicity against the human myeloid leukemia cell line (K562) with an IC50 value of 39.49 μM.

Key words

2-(2-phenylethyl)chromone dimers/Aquilaria crassna/Cytotoxicity/Red soil agarwood

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出版年

2022
Fitoterapia

Fitoterapia

SCI
ISSN：0367-326X
被引量5
参考文献量29
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