首页|Beneficial effects of novel aureobasidium pullulans strains produced beta-1,3-1,6 glucans on interleukin-6 and D-dimer levels in COVID-19 patients; results of a randomized multiple-arm pilot clinical study
Beneficial effects of novel aureobasidium pullulans strains produced beta-1,3-1,6 glucans on interleukin-6 and D-dimer levels in COVID-19 patients; results of a randomized multiple-arm pilot clinical study
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NSTL
Objective: In this pilot clinical study， we report the beneficial effects of beta glucans derived from two strains AFO-202 and N-163 of a black yeast Aureobasidium pullulans on the biomarkers for cytokine storm and coa-gulopathy in COVID-19 patients。 Methods: A total of 24 RT-PCR positive COVID-19 patients were recruited and randomly divided into three groups (Gr): Gr。 1 control (n = 8) - Standard treatment; Gr。 2: Standard treatment + AFO-202 beta glucan (n = 8); and Gr。 3， Standard treatment + combination of AFO-202 and N-163 beta glucans (n = 8) for 30 days。 Results: There was no mortality or requirement of ventilation of the subjects in any of the groups。 There was a decrease in D-Dimer values (751 ng/ml to 143。89 ng/ml) and IL-6 values (7。395-3。16 pg/ml) in Gr。 1 in 15 days but the levels increased to abnormal levels on day 30 (D-Dimer: 202。5 ng/ml; IL-6 55。37 pg/ml); which steadily decreased up to day 30 in groups 2 (D-dimer: 560。99 ng/dl to 79。615; IL-6: 26。18-3。41 pg/ml) and 3 (D-dimer: 1614 ng/dl to 164。25 ng/dl; IL-6: 6。25-0。5 pg/ml)。 The same trend was observed with ESR。 LCR and LeCR increased while NLR decreased significantly in Gr。 3。 CD4 + and CD8 + T cell count showed relatively higher increase in Gr。3。 There was no difference in CRP within the groups。 Conclusion: As these beta glucans are well known food supplements with a track record for safety， larger multi-centric clinical studies are recommended to validate their use as an adjunct in the management of COVID-19 and the ensuing long COVID-19 syndrome。
Gary A. Levy、Kadalraja Raghavan、Vidyasagar Devaprasad Dedeepiya、Vaddi Suryaprakash、Kosagi-Sharaf Rao、Nobunao Ikewaki、Tohru Sonoda、Masaru Iwasaki、Rajappa Senthilkumar、Senthilkumar Preethy、Samuel JK Abraham
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Dept of Paediatric Neurology, Kenmax Healthcare Services Pvt Ltd, Madurai, India
NSTL
