Tetrahedron letters2022，Vol.895.DOI:10.1016/j.tetlet.2021.153593

Electrochemical oxidation-induced benzyl C–H carbonylation for the synthesis of aromatic α-diketones

Tan Y.-F. Chen Y. Li R.-X. Guan Z. He Y.-H.
Tetrahedron letters2022，Vol.895.DOI:10.1016/j.tetlet.2021.153593
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  • NSTL
  • Elsevier

Electrochemical oxidation-induced benzyl C–H carbonylation for the synthesis of aromatic α-diketones

Tan Y.-F. 1Chen Y. 1Li R.-X. 1Guan Z. 1He Y.-H.1
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作者信息

  • 1. Key Laboratory of Applied Chemistry of Chongqing Municipality School of Chemistry and Chemical Engineering Southwest University
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Abstract

? 2021 Elsevier LtdElectrochemical oxidation-induced direct carbonylation of benzyl C–H bond for the synthesis of aromatic α-diketones is described. In this process, tetrabutylammonium iodide (nBu4NI) not only acts as an electrolyte, but its iodine anion is oxidized to an iodine radical at the anode, acting as a hydrogen atom transfer agent. The iodine radical extracts the benzyl hydrogen atom and causes the carbonylation of the benzyl position, where O2 in the air is used as an oxygen source.

Key words

Aromatic α-diketones/Benzyl C–H carbonylation/Benzyl radical/Electrochemical oxidation/Iodine-mediated reaction

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出版年

2022
Tetrahedron letters

Tetrahedron letters

CCR
ISSN：0040-4039
被引量1
参考文献量36
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