首页|Exploration of marine natural resources in Indonesia and development of efficient strategies for the production of microbial halogenated metabolites

Exploration of marine natural resources in Indonesia and development of efficient strategies for the production of microbial halogenated metabolites

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  • NSTL
  • Springer Nature
Nature is a prolific source of organic products with diverse scaffolds and biological activities. The process of natural product discovery has gradually become more challenging, and advances in novel strategic approaches are essential to evolve natural product chemistry. Our focus has been on surveying untouched marine resources and fermentation to enhance microbial productive performance. The first topic is the screening of marine natural products isolated from Indonesian marine organisms for new types of bioactive compounds, such as antineoplastics, antimycobacterium substances, and inhibitors of protein tyrosine phosphatase 1B, sterol O-acyl-transferase, and bone morphogenetic protein-induced osteoblastic differentiation. The unique biological properties of marine organohalides are discussed herein and attempts to efficiently produce fungal halogenated metabolites are documented. This review presents an overview of our recent work accomplishments based on the MONOTORI study. Graphic abstract

MONOTORIIndonesiaMarine invertebratesFungiOrganohalogensBiological activitiesTYROSINE-PHOSPHATASE 1BRESISTANT STAPHYLOCOCCUS-AUREUSLIPID DROPLET FORMATIONLISSOCLINUM CF. BADIUMCOACHOLESTEROL ACYLTRANSFERASE 2ENT-KAURENE DITERPENESINHIBITORY-ACTIVITYAERIAL PARTSENDOPHYTIC FUNGUSMOUSE MACROPHAGES

Yamazaki, Hiroyuki

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Fac Pharmaceut Sci,Tohoku Med & Pharmaceut Univ

2022

10.1007/s11418-021-01557-3

Journal of natural medicines

Journal of natural medicines

SCI
ISSN：1340-3443
年,卷(期)：2022.76(1)
  • 1
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