Tetrahedron letters2022，Vol.965.DOI:10.1016/j.tetlet.2022.153754

Pd-catalyzed Site-selective direct arene C-H arylation of Pyrrolo[2,3-d] pyrimidine derivatives with aryl iodides

Liu, Min Mao, Zhengtong Jiang, Yunfeng Zhang, Zhuo Zhang, Xingxian
Tetrahedron letters2022，Vol.965.DOI:10.1016/j.tetlet.2022.153754
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  • NSTL
  • Elsevier

Pd-catalyzed Site-selective direct arene C-H arylation of Pyrrolo[2,3-d] pyrimidine derivatives with aryl iodides

Liu, Min 1Mao, Zhengtong 1Jiang, Yunfeng 1Zhang, Zhuo 1Zhang, Xingxian1
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作者信息

  • 1. Zhejiang Univ Technol
  • 折叠

Abstract

A simple and efficient methodology was developed for the direct ortho C - H arylation of pyrrolo[2,3-d] pyrimidine derivatives. Aryl iodides are chosen as an arylating reagent for C(sp2)-H bond under Pd(II)/Pd (IV) catalysis in the presence of TFA, affording a diverse array of (hetero)biaryls-containing pyrrolo[2,3-d] pyrimidines in moderate to good yields with high regioselectivity and chemoselectivity.(c) 2022 Elsevier Ltd. All rights reserved.

Key words

C-H Arylation/Pyrrolo[2/3-d]pyrimidine Derivatives/High regioselectivity/Functional group tolerance/6-ARYLPURINE NUCLEOSIDES/RECENT PROGRESS/BOND ARYLATION/BTK INHIBITORS/FUNCTIONALIZATION/DISCOVERY/ACTIVATION/PYRROLOPYRIMIDINES/7-DEAZAPURINE/INDOLES

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出版年

2022
Tetrahedron letters

Tetrahedron letters

CCR
ISSN：0040-4039
被引量5
参考文献量80
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