首页|Organocatalytic one-pot asymmetric synthesis of 6-trifluoromethyl-substituted 7,8-dihydrochromen-6-ol
Organocatalytic one-pot asymmetric synthesis of 6-trifluoromethyl-substituted 7,8-dihydrochromen-6-ol
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NSTL
Elsevier
A squaramide organocatalyst efficiently promoted the asymmetric Friedel-Crafts alkylation of oc,6-unsat-urated trifluoromethyl ketones with aromatic alcohols in a one-pot procedure, affording corresponding 6trifluoromethyl-substituted 7,8-dihydrochromen-6-ol derivatives (up to 94% yield, 74% ee). (C)& nbsp;& nbsp;2022 Elsevier Ltd. All rights reserved.
NSTL
Elsevier
