Organocatalytic one-pot asymmetric synthesis of 6-trifluoromethyl-substituted 7,8-dihydrochromen-6-ol

Nakashima, Kosuke Minai, Asako Okuaki, Yuichi Matsushima, Yasuyuki Hirashima, Shin-ichi Miura, Tsuyoshi

Tetrahedron letters2022，Vol.955.DOI:10.1016/j.tetlet.2022.153733

来源：

NSTL
Elsevier

Organocatalytic one-pot asymmetric synthesis of 6-trifluoromethyl-substituted 7,8-dihydrochromen-6-ol

Nakashima, Kosuke ¹Minai, Asako ¹Okuaki, Yuichi ¹Matsushima, Yasuyuki ¹Hirashima, Shin-ichi ¹Miura, Tsuyoshi¹

扫码查看

作者信息

1. Tokyo Univ Pharm & Life Sci
折叠

Abstract

A squaramide organocatalyst efficiently promoted the asymmetric Friedel-Crafts alkylation of oc,6-unsat-urated trifluoromethyl ketones with aromatic alcohols in a one-pot procedure, affording corresponding 6trifluoromethyl-substituted 7,8-dihydrochromen-6-ol derivatives (up to 94% yield, 74% ee). (C)& nbsp;& nbsp;2022 Elsevier Ltd. All rights reserved.

Key words

Organocatalyst/Asymmetric conjugate addition/Chromane/One-pot/PYRROLIDINE-DIAMINOMETHYLENEMALONONITRILE ORGANOCATALYST/CONJUGATE ADDITION/ACTIVATED PHENOLS/VITAMIN-E/NITROOLEFINS/NITROALKENES/DERIVATIVES/ALDEHYDES/NAPHTHOLS

引用本文复制引用

出版年

2022

Tetrahedron letters

CCR

ISSN：0040-4039

被引量2

参考文献量69

段落导航