首页|Correlation of amniotic fluid index and placental aquaporin 1 levels in terms of preeclampsia
Correlation of amniotic fluid index and placental aquaporin 1 levels in terms of preeclampsia
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NSTL
Elsevier
Introduction: Aquaporin 1 (AQP1) plays an important role in regulation of maternal-fetal fluid exchange and amniotic fluid volume. This present study aimed to determine the relationship between amniotic fluid index and placental AQP1 levels in terms of preeclampsia, and to reveal possible pathophysiological changes of AQP1 expression under preeclamptic conditions. Methods: Placental tissues and medical records information were obtained from 389 preeclamptic and 447 un-complicated pregnancies. Placental AQP1 levels were analyzed by molecular biological methods, DNA methyl-ation within gene promotor was determined by targeted bisulfite sequencing assay Results: Here, we found that preeclamptic pregnancy had a greater frequency of oligohydramnios, and higher placental AQP1 levels. There was a significantly inverse correlation between amniotic fluid index and placental AQP1 levels in preeclampsia cases. Additionally, the increased AQP1 was correlated with a decreased DNA methylation within its gene promoter. Discussion: Overall, this was the first description that a greater frequency of oligohydramnios in preeclampsia was strongly associated with reprogrammed AQP1 expression via a DNA methylation-mediated epigenetic mecha-nism. This study suggested AQP1 might play an important role in regulating maternal-fetal fluid balance under preeclamptic conditions, providing new information for further understanding the pathophysiological mecha-nism of oligohydramnios in preeclampsia.
NSTL
Elsevier
