首页|Enhancing reuse of structured eligibility criteria and supporting their relaxation
Enhancing reuse of structured eligibility criteria and supporting their relaxation
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NSTL
Elsevier
Patient recruitment is one of the most important barriers to successful completion of clinical trials and thus to obtaining evidence about new methods for prevention, diagnostics and treatment. The reason is that recruitment is effort consuming. It requires the identification of candidate patients for the trial (the population under study), and verifying for each patient whether the eligibility criteria are met. The work we describe in this paper aims to support the comparison of population under study in different trials, and the design of eligibility criteria for new trials. We do this by introducing structured eligibility criteria, that enhance reuse of criteria across trials. We developed a method that allows for automated structuring of criteria from text. Additionally, structured eligibility criteria allow us to propose suggestions for relaxation of criteria to remove potentially unnecessarily restrictive conditions. We thereby increase the recruitment potential and generalizability of a trial.
Formalizing eligibility criteriaSupporting trial designSemantic annotationPopulating ontology from textData visualization
Milian, Krystyna、Hoekstra, Rinke、Bucur, Anca、ten Teije, Annette、van Harmelen, Frank、Paulissen, John
NSTL
Elsevier
