New diketopiperazine alkaloid and polyketides from marine-derived fungus Penicillium sp. TW58-16 with antibacterial activity against Helicobacter pylori

Tian, Danmei ¹Gou, Xiaoshuang ¹Jia, Jia ²Wei, Jihua ³Zheng, Mingxin ²Ding, Wenjuan ¹Bi, Hongkai ²Wu, Bin ³Tang, Jinshan¹

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作者信息

1. Jinan Univ
2. Nanjing Med Univ
3. Zhejiang Univ
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Abstract

Marine-derived fungi can usually produce structurally novel and biologically potent metabolites. In this study, a new diketopiperazine alkaloid (1) and two new polyketides (10 and 11), along with 8 known diketopiperazine alkaloids (2-9) were isolated from marine-derived fungus Penicillium sp. TW58-16. Their structures were fully elucidated by analyzing UV, IR, HR-ESI-MS, 1D, and 2D NMR spectroscopic data. The absolute configurations of the new compounds 1, 10 and 11 were ascertained by X-ray diffraction (Cu K alpha radiation) and comparing their CD data with those reported. In addition, the antibacterial activities of these compounds against Helicobacter pylori in vitro were assessed. Results showed that compounds 3, 6, 8 and 9 displayed moderate antibacterial activity against standard strains and drug-resistant clinical isolates of H. pylori in vitro. This result demonstrates that diketopiperazine alkaloids could be lead compounds to be explored for the treatment of H. pylori infection.

Key words

Penicillium sp/Diketopiperazine alkaloid/Polyketide/Antibacterial activity/H/pylori/ENDOPHYTIC FUNGUS/ASPERGILLUS-FUMIGATUS/SECONDARY METABOLITES/OKARAMINE CONGENERS/NATURAL-PRODUCTS

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出版年

2022

Fitoterapia

SCI

ISSN：0367-326X

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