Two undescribed phenolic derivatives musaones A and B, six undescribed gamma-butyrolactone musaolides A-F, together with two undescribed cyclopentanone musaolides G and H were isolated from the solid culture of an endophytic strain Phaeosphaeriopsis musae M. Arzanlou & Crous (Phaeosphaeriaceae). Their structures were unambiguously elucidated by extensive spectral analyses. The absolute configurations of two diastereomers musaolides G and H were assigned by comparing their experimental and calculated ECD data. Moreover, the in vitro alpha-glucosidase inhibition and cytotoxic activities of isolated compounds (except musaolide D) were evaluated to understand their biological effects, wherein musaone B and musaolide F displayed promising alpha-glucosidase inhibition with IC50 values of 37.3 +/- 0.59 mu M and 105.18 +/- 2.76 mu M respectively, compared to the positive control acarbose (24.99 +/- 1.28 mu M).
NSTL
Elsevier