Fitoterapia2022，Vol.1596.DOI:10.1016/j.fitote.2022.105204

Datinolides E-I, five new withanolides with anti-inflammatory activity from the leaves of Datura inoxia Mill

Wu, Jia-Tong Liu, Yan Jiang, Yi-Kai Wang, Si-Yi Jiang, Chen-Yu Algradi, Adnan Mohammed Pan, Juan Guan, Wei Kuang, Hai-Xue Yang, Bing-You
Fitoterapia2022，Vol.1596.DOI:10.1016/j.fitote.2022.105204
✕
  • NSTL
  • Elsevier

Datinolides E-I, five new withanolides with anti-inflammatory activity from the leaves of Datura inoxia Mill

Wu, Jia-Tong 1Liu, Yan 1Jiang, Yi-Kai 1Wang, Si-Yi 1Jiang, Chen-Yu 1Algradi, Adnan Mohammed 1Pan, Juan 1Guan, Wei 1Kuang, Hai-Xue 1Yang, Bing-You1
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作者信息

  • 1. Heilongjiang Univ Chinese Med
  • 折叠

Abstract

Five new withanolides, datinolides E-I (1-5), and three known withanolides (6-8) were separated from Datura inoxia Mill. leaves, and datinolide E (1) was the first withanolide with C-27 connected to a nitrogen-containing group. Their structures were clarified by comprehensive spectroscopic analysis and comparison with literature. The anti-inflammatory of isolated compounds against RAW264.7 cells was investigated by the CCK8 assay.

Key words

Datura inoxia Mill/Withanolide/Anti-inflammatory activities/Solanaceae/AERIAL PARTS

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出版年

2022
Fitoterapia

Fitoterapia

SCI
ISSN：0367-326X
参考文献量16
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