首页|New acylglycosides from the roots of Rheum palmatum L.
New acylglycosides from the roots of Rheum palmatum L.
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NSTL
Elsevier
? 2022A phytochemical investigation of the EtOH extract of the roots of Rheum palmatum L. was performed, leading to the isolation of 3 new acylglycosides (1–3) and 19 previously reported compounds, including 4 cinnamoyl glucosides (4–7) and 15 anthraquinones (8–22). Their structures were elucidated using nuclear magnetic resonance, infrared, ultraviolet and high-resolution electrospray ionization mass spectra and X-ray diffraction data. The biological activities of compounds 2, 4–9, and 11–13, including their lymphocyte activation gene 3 (LAG3)/major histocompatibility complex class II (MHC II) and LAG3/fibrinogen-like protein 1 (FGL1) binding inhibition activities, were evaluated. Among the isolates, compound 7 exhibited clear inhibitory activity against the LAG3/FGL1 interaction with an IC50 of 7.89 μM, meanwhile compound 6 inhibited the LAG3/MHC II interaction with an IC50 of 6.00 μM.
AcylglycosidesAnthraquinoneLAG3/FGL1LAG3/MHC IIRheum palmatum L.
Feng W.-J.、Yang H.-Y.、He Y.-L.、Li Y.、Gao K.
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State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University
NSTL
Elsevier
