Tetrahedron letters2022，Vol.896.DOI:10.1016/j.tetlet.2021.153600

Palladium catalyzed nitrile insertion and cyanation of biindoles: Synthesis of indole fused α-carboline scaffolds via double C–H activation

Kalyani A. Tulichala R.N.P. Chauhan S. Swamy K.C.K.
Tetrahedron letters2022，Vol.896.DOI:10.1016/j.tetlet.2021.153600
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  • NSTL
  • Elsevier

Palladium catalyzed nitrile insertion and cyanation of biindoles: Synthesis of indole fused α-carboline scaffolds via double C–H activation

Kalyani A. 1Tulichala R.N.P. 1Chauhan S. 1Swamy K.C.K.1
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作者信息

  • 1. School of Chemistry University of Hyderabad
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Abstract

? 2021 Elsevier LtdA palladium-catalyzed synthesis of indole fused α-carbolines (pyridodiindoles) from 2,3′-biindoles and nitriles has been developed. This conversion involves the double C–H activation and cyclization of 2,3′-biindoles with nitriles via C–C and C–N bond formation in a single step. However, C-3 cyanated biindoles were formed through a retro-Mannich pathway when the reaction was carried out with ethyl cyanoacetate.

Key words

Biindole/Cyclization/C–H activation/Nitrile insertion/Palladium catalysis/α-Carbolines (pyridodiindoles)

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出版年

2022
Tetrahedron letters

Tetrahedron letters

CCR
ISSN：0040-4039
被引量4
参考文献量56
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