首页|Fragmentation pathways of metopimazine and its metabolite using ESI-MSn, HR-MS and H/D exchange

Fragmentation pathways of metopimazine and its metabolite using ESI-MSn, HR-MS and H/D exchange

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  • NSTL
  • Wiley
Metopimazine (MPZ) is a phenothiazine derivative used to prevent emesis during chemotherapy where few structural analysis of the aforementioned compound have been described in the literature. Thus, this work reports, for the first time, the detailed study of fragmentation pathways of MPZ and its metabolite (AMPZ) using electrospray ionization (EI) with multistage mass spectrometry (ESI-MSn) in positive-ion mode. The structures of 21 product ions were identified and their accurate masses were determined using high resolution mass spectrometry (HRMS) experiments. Characteristic product ions of these two phenothiazine derivatives are more particularly displayed along with differences between their relative abundances and their structures checked by H/D exchange experiments.

metopimazinephenothiazinefragmentationESI-MSnHR-MS

Hubert-Roux, Marie、Bounoure, Frédéric、Skiba, Mohamed、Bozec, Philippe、Churlaud, Florence、Lange, Catherine M.

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Université de Rouen, IRCOF, 76821 Mont-Saint-Aignan Cedex, France

Laboratoire de Pharmacie Galénique, LAGEP UMR CNRS 5007, Université de Rouen, 22 bd Gambetta, 76000 Rouen, France

Arkema, Centre d'Etude de Recherche et Développement, 27470 Serquigny, France

2010

10.1002/jms.1790

Journal of mass spectrometry

Journal of mass spectrometry

AHCIEI
ISSN：1076-5174
年,卷(期)：2010.45(10)
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