Abstract
Weakly coordinating functional groups such as keto and ester of common feedstock chemicals have been used efficiently as directing groups for sustainable manganese-catalyzed C-H bond functionalization reactions. This approach is successfully applied in developing C-H addition to oxiranes, imines, olefins, allylic electrophiles, azides, aldehydes and isocyanates via C-C and C-N bonds formation. In some cases reaction cascades resulting in annulated products have also been observed. In this perspective we summarizes on the current developments in organometallic manganese-catalyzed C-H functionalizations driven via weak coordination and have pointed out challenges/opportunities for future catalytic improvements. The mechanistic studies done so far on this emerging topic of manganese catalysis have revealed low valent (0 and +1) manganese complexes more efficient for these transformations. (C) 2022 Elsevier Ltd. All rights reserved.
NSTL
Elsevier