首页|New metabolites (±)-bacillipyrrole A and bacillipyrazine A from the Mariana Trench-associated bacterium Bacillus subtilis SY2101

New metabolites (±)-bacillipyrrole A and bacillipyrazine A from the Mariana Trench-associated bacterium Bacillus subtilis SY2101

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  • NSTL
  • Elsevier
? 2022 Phytochemical Society of EuropeThe new (±)-bacillipyrrole A (1) and bacillipyrazine A (2), together with seven known compounds, were isolated from a culture of the Mariana Trench sediment-derived bacterium Bacillus subtilis SY2101 in rice medium. Structures of the new compounds were elucidated by their HRESIMS data and NMR spectroscopic analyses. The known compound 3,5,6-trimethylpyrazine-2-methyl acetate (4) showed antiproliferative activity against human glioma U87MG cells with an IC50 value of 22.6 ± 2.8 μM.

(±)-Bacillipyrrole AAntiglioma activityBacillipyrazine ABacillus subtilis SY2101Marine-derived bacterium

Qin L.、Yong K.、Zhang Z.、Lian X.-Y.

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Ocean College Zhoushan Campus Zhejiang University

College of Pharmaceutical Sciences Zhejiang University

2022

10.1016/j.phytol.2022.03.010

Phytochemistry Letters

Phytochemistry Letters

SCI
ISSN：1874-3900
年,卷(期)：2022.49
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