首页|Role of plant biotechnology in enhancement of alkaloid production from cell culture system of Catharanthus roseus: A medicinal plant with potent anti-tumor properties
Role of plant biotechnology in enhancement of alkaloid production from cell culture system of Catharanthus roseus: A medicinal plant with potent anti-tumor properties
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NSTL
Elsevier
Catharanthus roseus is one of the most valuable plants due to its medicinal value. This has made C. roseus so important for the pharmaceutical industry. However, the low productivity and high demand of the plant led to deviation from conventional mode to unconventional using biotechnological tools. This review article discusses the in vitro techniques of genetic improvement of C. roseus and techniques adopted to analyse the biochemical factors associated with the biosynthesis pathway. In vitro culture of C. roseus enhanced the rate of production and multiplication as compared to conventional breeding techniques. Different methods of in vitro culture were investigated to obtain the best results by using different plant growth regulators (PGRs). The stress has been used as an efficient tool to enhance the alkaloid content. Stress-induced culture showed several fold increases in the pharmacologically important alkaloid production. Several biotic and abiotic factors have been used for stress induction in the culture. Genetic manipulation of the biosynthesis pathways by overexpressing vital genes involved in the biosynthesis of alkaloids. Omics tools immensely supported the study of C. roseus and increased our understanding of its genome structure, genes involved and candidate proteins involved in alkaloid production.
NSTL
Elsevier
