Phytochemistry2022，Vol.1949.DOI:10.1016/j.phytochem.2021.113015

Isoquinoline alkaloid dimers with dopamine D1 receptor activities from Menispermum dauricum DC

Wei, Hong-Li Han, Yang Zhou, Han Hou, Tao Yao, Yu-Min Wen, Chun-Mei Wang, Chao-Ran Wang, Ji-Xia Shen, Ai-Jin Zhang, Xiu-Li Li, Hao Liu, Yan-Fang
Phytochemistry2022，Vol.1949.DOI:10.1016/j.phytochem.2021.113015
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  • NSTL
  • Elsevier

Isoquinoline alkaloid dimers with dopamine D1 receptor activities from Menispermum dauricum DC

Wei, Hong-Li 1Han, Yang 1Zhou, Han 1Hou, Tao 1Yao, Yu-Min 1Wen, Chun-Mei 2Wang, Chao-Ran 1Wang, Ji-Xia 1Shen, Ai-Jin 1Zhang, Xiu-Li 3Li, Hao 2Liu, Yan-Fang1
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作者信息

  • 1. Chinese Acad Sci
  • 2. Ganjiang Chinese Med Innovat Ctr
  • 3. Soochow Univ
  • 折叠

Abstract

A phytochemical investigation on chemical constituents from the rhizomes of Menispermum dauricum DC. identified eight undescribed dimeric alkaloids with structurally diverse monomeric isoquinoline. Alkaloid structures were elucidated by a combination of spectroscopic data analyses and time-dependent density functional theory (TDDFT) ECD calculation. The isolates were evaluated for inhibitory effect on dopamine D1 receptor and compound 1 exhibited potent D1 receptor antagonistic activity with an IC50 value of 8.4 +/- 2.0 mu M.

Key words

Menispermum dauricum DC/Menispermaceae/Dimeric isoquinoline alkaloids/Electronic circular dichroism/D1 antagonistic activity

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出版年

2022
Phytochemistry

Phytochemistry

CCR
ISSN：0031-9422
被引量1
参考文献量22
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