首页|A new β-hydroxydihydrochalcone from Tephrosia uniflora, and the revision of three β-hydroxydihydrochalcones to flavanones

A new β-hydroxydihydrochalcone from Tephrosia uniflora, and the revision of three β-hydroxydihydrochalcones to flavanones

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  • NSTL
  • Elsevier
? 2022 The Author(s)The CH2Cl2/MeOH (1:1) extract of the stems of Tephrosia uniflora yielded the new β-hydroxydihydrochalcone (S)-elatadihydrochalcone-2'-methyl ether (1) along with the three known compounds elongatin (2), (S)-elatadihydrochalcone (3), and tephrosin (4). The structures were elucidated by NMR spectroscopic and mass spectrometric data analyses. Elongatin (2) showed moderate antibacterial activity (EC50 of 25.3 μM and EC90 of 32.8 μM) against the Gram-positive bacterium Bacilus subtilis, and comparable toxicity against the MCF-7 human breast cancer cell line (EC50 of 41.3 μM). Based on the comparison of literature and predicted NMR data with that obtained experimentally, we propose the revision of the structures of three β-hydroxydihydrochalcones to flavanones.

Antibacterial activityElongatinFlavanoneStructure revisionTephrosia unifloraβ-Hydroxydihydrochalcone

Ndakala A.、Chepkirui C.、Derese S.、Yenesew A.、Bourgard C.、Gutlin Y.、Gilissen P.J.、Erdelyi M.

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Department of Chemistry University of Nairobi

Department of Chemistry and Molecular Biology Center for Antibiotic Resistance Research (CARe) University of Gothenburg

Institute for Molecules and Materials Radboud University

Department of Chemistry - BMC Uppsala University

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2022

10.1016/j.fitote.2022.105166

Fitoterapia

Fitoterapia

SCI
ISSN：0367-326X
年,卷(期)：2022.158
  • 37