首页|Effect of excipient particle size distribution variability on compact tensile strength; and its in-line prediction by force-displacement and force-time profiling
Effect of excipient particle size distribution variability on compact tensile strength; and its in-line prediction by force-displacement and force-time profiling
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NSTL
Elsevier
Background: Direct compression is potentially sensitive to particle size distribution (PSD) variability in pharmaceutical grade excipients. Yet, the impact is insufficiently studied. Furthermore, the use of force sensor as a process analytical technology (PAT) platform, to monitor the effect of PSD variations on compact tensile strength, is a readily available but underutilized strategy.
Process analytical technologyTabletCompactionTensile strengthParticle size distributionExcipient variability
Lee, Wee Beng、Widjaja, Effendi、Heng, Paul Wan Sia、Chan, Lai Wah
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Natl Univ Singapore, Dept Pharm, GEA NUS Pharmaceut Proc Res Lab, 18 Sci Dr 4, Singapore 117543
MSD Int GmbH, 50 Tuas West Dr, Singapore 638408, Singapore
NSTL
Elsevier
