首页|Nanotraps based on multifunctional materials for trapping and enrichment

Nanotraps based on multifunctional materials for trapping and enrichment

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Many biomarkers for early diagnosis of cancer and other diseases are difficult to detect because they of -ten exist in body fluids in very low concentrations and are masked by high-abundance proteins such as albumin and immunoglobulins. At the same time, water pollution is one of the most serious environmen-tal problems, but the existing adsorption materials have many shortcomings such as slow kinetics, small adsorption capacity and low adsorption efficiency. Nanotraps, mixed with gases or liquids, can capture and concentrate target substances, such as biomolecules, metal ions and oxoanions. Using nanotraps is a versatile sample pre-processing approach and it can improve the sensitivity of downstream analysis tech-niques. Herein, the preparations and applications of different types of nanotraps are mainly introduced. What's more, the shortcomings of using nanotraps in practical applications are also discussed. Using nan-otraps is a promising sample pre-processing technology, which is of great significance for biomarkers discovery, diseases diagnosis, sewage purification and valuable ions recovery. Statement of significance This review collates and summarizes the preparations and applications of different types of nanotraps, and discusses the shortcomings of using nanotraps in practical applications. Nanotraps, mixed with gases or liquids, can capture and concentrate target materials, such as biomolecules, metal ions and oxoan-ions. Using nanotraps is a versatile sample pre-processing approach and it can improve the sensitivity of downstream analysis techniques. During the COVID-19 pandemic, hydrogel nanotraps were successfully utilized for RT-PCR analysis with the FDA Emergency Used Authorization for COVID-19. Using nanotraps is a promising sample pre-processing technology, which is of great significance for biomarkers discovery, diseases diagnosis, sewage purification and valuable ions recovery. (c) 2021 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

NanotrapsPre-processing technologyApplicationBiomoleculesIonsORGANIC POLYMERSNANO-TRAPLIGNINNANOPARTICLESPURIFICATIONEXPRESSIONPARTICLESCAPTURESURFACE

Xu, Wenxin、Xu, Na、Zhang, Manyue、Wang, Yan、Ling, Guixia、Yuan, Yue、Zhang, Peng

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Shenyang Pharmaceut Univ

2022

Acta biomaterialia

Acta biomaterialia

EISCI
ISSN:1742-7061
年,卷(期):2022.138
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