首页|The Role of Pituitary Adenylate Cyclase-Activating Polypeptide and Vasoactive Intestinal Peptide in Migraine Pathogenesis
The Role of Pituitary Adenylate Cyclase-Activating Polypeptide and Vasoactive Intestinal Peptide in Migraine Pathogenesis
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NSTL
Springer Nature
In this review, we summarize the experimental and clinical data supporting the role of pituitary adenylate cyclase-activating peptide (PACAP) and vasoactive intestinal peptide (VIP) in the pathophysiology of primary headaches, including migraine. We provide evidence of the involvement of these mediators and their receptors in nociception and vascular tone regulation, especially within the trigeminovascular system. The anticephalalgic potential of pharmacological agents blocking the PACAP-ergic pathway is also discussed.
NSTL
Springer Nature
