Abstract
? 2021 Elsevier LtdHerein we present the plain manufacture of sterically hindered tertiary alkyl thioethers via the Cu-catalyzed coupling of unactivated tertiary alkyl alcohols with thio-alcohols/phenols. The present strategy with easy-to-operate reaction conditions represents one of the most effective unactivated tertiary C(sp3)–S bond-forming methods via readily accessible Lewis acid catalysis. Moreover, this protocol has high functional group compatibility and wide substrate adaptability.
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Elsevier