首页|Topical delivery of pluronic F127/TPGS mixed micelles-based hydrogel loaded with glycyrrhizic acid for atopic dermatitis treatment
Topical delivery of pluronic F127/TPGS mixed micelles-based hydrogel loaded with glycyrrhizic acid for atopic dermatitis treatment
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NSTL
Taylor & Francis
Objective The purpose of this study was to develop pluronic F127/d-a-tocopheryl polyethylene glycol 1000 succinate mixed micelles-based hydrogel (MMs-gel) for topical delivery of glycyrrhizic acid (GL) to improve its skin permeability and atopic dermatitis (AD) treatment。 Significance GL loaded MMs-gel (GL-MMs-gel) could be potentially used as a promising nanocarrier for the treatment of AD。 Methods GL-MMs were prepared by thin film hydration method and then loaded into carbopol gel。 The formulation of GL-MMs-gel was optimized by full factorial design and systematically characterized for drug content， pH， spreadability， in vitro drug release and percutaneous permeation， etc。 The therapeutic effect of GL-MMs-gel was also investigated in AD-like skin lesion model in BALB/c mice and compared with GL solution-based gel (GL-sol-gel)。 Results Spherical GL-MMs with particle size of similar to 30 nm were successfully incorporated into carbopol gel to form GL-MMs-gel with drug content of (98。80 +/- 1。30) %， pH of 6。0 +/- 0。08， and spreadability of (7。1 +/- 0。2) cm。 In vitro drug release profile of GL-MMs-gel exhibited a sustained-release behavior。 The permeation flux for GL-MMs-gel (5。15 +/- 0。33 mu g/cm(2)/h) was significantly higher than that of GL-sol-gel (3。08 +/- 0。34 mu g/cm(2)/h) and GL-MMs-gel increased the accumulative amounts of GL in rats' skin 8。41 times than GL-sol-gel。 The GL-MMs-gel was more effective than GL-sol-gel in suppressions of various AD symptoms including skin lesions， edema， high IgE levels， epidermal hyperplasia， and mast cell infiltration。 Conclusion All results revealed that MMs-gel could be a promising carrier for topical delivery of GL for the treatment of AD。
NSTL
Taylor & Francis
