首页|Placental MFSD2a transporter is related to decreased DHA in cord blood of women with treated gestational diabetes

Placental MFSD2a transporter is related to decreased DHA in cord blood of women with treated gestational diabetes

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  • NSTL
  • Elsevier
Background & aims: Maternal-fetal transfer of docosahexaenoic acid (DHA) is impaired by gestational diabetes mellitus (GDM), but the underlying mechanisms are still unknown. MFSD2a was recently recognized as a lyso-phospholipid (lyso-PL) transporter that facilitates DHA accretion in brain. The role of this transporter in placenta is uncertain. We evaluated effects of GDM and its treatment (diet or insulin) on phospholipid species, fatty acid profile in women, cord blood and placental fatty acid carriers.

MFSD2aOmega-3 fatty acidsDiabetesLysophospholipidsPlacentaFatty acids transport

Ruiz-Palacios, Maria、Prieto-Sanchez, Maria T.、Blanco-Carnero, Jose E.、Pagan, Ana、Hellmuth, Christian、Uhl, Olaf、Peissner, Wolfgang、Ruiz-Alcaraz, Antonio J.、Parrilla, Juan J.、Koletzko, Berthold、Larque, Elvira

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Univ Murcia, Dept Physiol, Fac Biol, Campus Mare Nostrum, Murcia, Spain

Univ Murcia, Virgen de la Arrixaca Clin Hosp, Obstet & Gynecol Serv, Murcia, Spain

Ludwig Maximilians Univ Munchen, Dr von Hauner Childrens Hosp, Munich, Germany

Univ Murcia, Dept Biochem Mol Biol & Immunol B, Murcia, Spain

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2017

10.1016/j.clnu.2016.01.014

Clinical nutrition

Clinical nutrition

ISTP
ISSN：0261-5614
年,卷(期)：2017.36(2)
  • 43
  • 32