首页|Genome-Wide Association Study of Clinical Outcome After Aneurysmal Subarachnoid Haemorrhage: Protocol

Genome-Wide Association Study of Clinical Outcome After Aneurysmal Subarachnoid Haemorrhage: Protocol

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  • NSTL
  • Springer Nature
Aneurysmal subarachnoid haemorrhage (aSAH) results in persistent clinical deficits which prevent survivors from returning to normal daily functioning. Only a small fraction of the variation in clinical outcome following aSAH is explained by known clinical, demographic and imaging variables; meaning additional unknown factors must play a key role in clinical outcome. There is a growing body of evidence that genetic variation is important in determining outcome following aSAH. Understanding genetic determinants of outcome will help to improve prognostic modelling, stratify patients in clinical trials and target novel strategies to treat this devastating disease. This protocol details a two-stage genome-wide association study to identify susceptibility loci for clinical outcome after aSAH using individual patient-level data from multiple international cohorts. Clinical outcome will be assessed using the modified Rankin Scale or Glasgow Outcome Scale at 1-24 months. The stage 1 discovery will involve meta-analysis of individual-level genotypes from different cohorts, controlling for key covariates. Based on statistical significance, supplemented by biological relevance, top single nucleotide polymorphisms will be selected for replication at stage 2. The study has national and local ethical approval. The results of this study will be rapidly communicated to clinicians, researchers and patients through open-access publication(s), presentation(s) at international conferences and via our patient and public network.

Subarachnoid haemorrhageStrokeOutcome assessmentHealth careGeneticsMedicalCEREBRAL VASOSPASMPOLYMORPHISMGENOTYPEISCHEMIAINJURYALLELETIME

Bulters, Diederik、Tapper, Will、Gaastra, Ben、Alexander, Sheila、Bakker, Mark K.、Bhagat, Hemant、Blackburn, Spiros、Collins, Malie K.、Dore, Sylvain、Griessenauer, Christoph、Hendrix, Philipp、Hong, Eun Pyo、Hostettler, Isabel C.、Houlden, Henry、IIhara, Koji、Jeon, Jin Pyeong、Kim, Bong Jun、Kumar, Munish、Morel, Sandrine、Nyquist, Paul、Bijlenga, Philippe、Ren, Dianxu、Ruigrok, Ynte M.、Werring, David、Galea, Ian

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Wessex Neurol Ctr,Univ Hosp Southampton

Fac Med,Univ Southampton

Sch Nursing,Univ Pittsburgh

Brain Ctr,Univ Med Ctr Utrecht

Dept Anaesthesia & Intens Care,Postgrad Inst Med Educ & Res PGIMER

Hlth Sci Ctr,Univ Texas Houston

Geisinger Commonwealth Sch Med

Coll Med,Univ Florida

Dept Neurosurg,Geisinger

Inst New Frontier Res,Hallym Univ

Stroke Res Ctr,UCL

Natl Cerebral & Cardiovasc Ctr Hosp

Fac Med,Geneva Univ Hosp

Dept Neurol,Johns Hopkins Sch Med

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2022

10.1007/s12975-021-00978-2

Translational stroke research

Translational stroke research

SCI
ISSN：1868-4483
年,卷(期)：2022.13(4)
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